Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1

MeSH terms

• Administration, Oral
• Amines / chemical synthesis*
• Amines / chemistry
• Amines / pharmacology*
• Animals
• Antineoplastic Agents / chemical synthesis*
• Antineoplastic Agents / chemistry
• Antineoplastic Agents / pharmacology*
• Cell Cycle Proteins / antagonists & inhibitors*
• Combinatorial Chemistry Techniques
• Crystallography, X-Ray
• Drug Screening Assays, Antitumor
• Imidazoles / chemical synthesis*
• Imidazoles / chemistry
• Imidazoles / pharmacology*
• Mice
• Models, Molecular
• Molecular Conformation
• Molecular Structure
• Polo-Like Kinase 1
• Protein Serine-Threonine Kinases / antagonists & inhibitors*
• Proto-Oncogene Proteins / antagonists & inhibitors*
• Structure-Activity Relationship
• Triazines / chemical synthesis*
• Triazines / chemistry
• Triazines / pharmacology